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    Prescription under medical supervision


    Therapeutic action

    • Sulfonylurea antidiabetic


    • Second-line treatment of type 2 diabetes, in patients over 60 years:
      • as monotherapy, when metformin is not tolerated or contra-indicated
      • in combination with metformin, when glycaemic control is inadequate with metformin alone

    Forms and strengths

    • 80 mg scored tablet 

    Dosage and duration

    • Adult:  

    Weeks 1 and 2: 40 mg once daily in the morning
    Increase if necessary in increments of 40 mg every 2 weeks, according to blood glucose levels (Weeks 3 and 4: 80 mg once daily in the morning). 
    The usual dose is 80 to 160 mg daily (max. 240 mg daily).

    Contra-indications, adverse effects, precautions

    • Do not administer in the event of:
      • allergy to sulfonamides;
      • type 1 diabetes, juvenile diabetes, ketoacidosis;
      • severe renal or hepatic impairment.
    • May cause: hypoglycaemia, gastrointestinal disturbances, weight gain; rarely, allergic reactions.
    • Monitor combination with:
      • diuretics, angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatories, azole antifungals (fluconazole, miconazole), ciprofloxacin, erythromycin, co-trimoxazole (enhanced hypoglycaemic effect);
      • rifampicin (decreased hypoglycaemic effect);
      • drugs increasing blood glucose levels: corticosteroids, hydrochlorothiazide, salbutamol, chlorpromazine.
    • Avoid combination with alcohol (risk of hypoglycaemia).
    • Pregnancy: avoid. Insulin is the drug of choice for the treatment of type 2 diabetes in pregnant women (improved glycaemic control; reduced risk of foetal anomalies and neonatal complications).
    • Breast-feeding: CONTRA-INDICATED


    • Take with meals (reduced risk of gastrointestinal disturbances).
    • For doses greater than 80 mg daily, divide the daily dose into 2 doses.
    • Also comes in 30 and 60 mg modified release tablets.


    - Below 25 °C