DARUNAVIR = DRV

Therapeutic action

• Antiretroviral, HIV protease inhibitor

Indications

• HIV infection, in combination with ritonavir (booster) and other antiretrovirals

Forms and strengths

• 75 mg, 300 mg, 400 mg and 600 mg tablets

Dosage

Patients with no previous use of protease inhibitors

• Child 14 to < 35 kg: 600 mg once daily (+ 100 mg ritonavir once daily)
• Child ≥ 35 kg and adult: 800 mg once daily (+ 100 mg ritonavir once daily)

Patients with previous use of protease inhibitors

• Child 14 to < 25 kg: 375 mg 2 times daily (+ 50 mg ritonavir 2 times daily)
• Child 25 to < 35 kg: 400 mg 2 times daily (+ 100 mg ritonavir 2 times daily)
• Child ≥ 35 kg and adult: 600 mg 2 times daily (+ 100 mg ritonavir 2 times daily)

Duration

• The duration of treatment depends on the efficacy and tolerance of darunavir and ritonavir.

Contra-indications, adverse effects, precautions

• Do not administer in children under 3 years; in case of severe hepatic impairment, history of allergy to sulfonamides or in combination with rifampicin.
• Administer with caution and monitor use in patients with haemophilia (increased bleeding) or in patients with mild or moderate hepatic impairment.
• May cause:
  • gastrointestinal disturbances, headache, insomnia, fatigue, dizziness, peripheral neuropathy, renal disorders, myocardial infarction, hypertension, tachycardia, hyperglycaemia, hyperlipidaemia, lipodystrophy;
  • skin rash sometimes severe, hepatic disorders; in this event, stop treatment immediately.
• Darunavir in combination with ritonavir reduces the efficacy of oral contraceptives: use a non-hormonal contraception or injectable medroxyprogesterone or an oral contraceptive containing 50 micrograms of ethinylestradiol per tablet.
• Pregnancy: no contra-indication

Remarks

• Take with meals together with ritonavir.

Storage