– Antiretroviral, HIV protease inhibitor
– Booster for protease inhibitors (atazanavir, darunavir, etc.) in HIV infection. Ritonavir should not be used alone.
Forms and strengths
– 25 mg and 100 mg tablets
– 80 mg/ml oral solution, containing 43% alcohol (v/v), with a graduated syringe for oral administration
Also comes in fixed dose combinations containing ritonavir.
Dosage depends on the administration schedule of the boosted protease inhibitor.
– Child 10 to < 14 kg: 40 mg 2 times daily
– Child 14 to < 25 kg: 50 mg 2 times daily or 100 mg once daily
– Child ≥ 25 kg and adult: 100 mg once or 2 times daily
80 mg/ml oral sol.*
25 mg tab
100 mg tab
|10 to < 14 kg||0.5 ml x 2||–||–|
|14 to < 25 kg||0.6 ml x 2 |
or 1.25 ml x 1
2 tab x 2
|≥ 25 kg and adult||–||–||1 tab x 1 or 2|
* For doses less than 0.8 ml, use a 1 ml syringe graduated 0.01 ml.
– The duration of treatment depends on the efficacy and tolerance of the boosted protease inhibitor and ritonavir.
Contra-indications, adverse effects, precautions
– Do not administer to patients with severe hepatic impairment.
– Administer with caution and monitor use in patients with haemophilia (increased bleeding).
– The adverse effects of ritonavir as a booster are also dependent on the boosted protease inhibitor.
– May cause:
• gastrointestinal disturbances, fatigue, headache, dizziness, paraesthesia, joint and muscle pain, hyperglycaemia, lipodystrophy, conduction disorders;
• pancreatitis, hepatic disorders, skin rash sometimes severe; in this event, stop treatment immediately.
– Administer with caution and monitor combination with metronidazole when using oral solution of ritonavir that contains alcohol (risk of antabuse reaction).
– Ritonavir reduces the efficacy of oral contraceptives.
– Pregnancy: CONTRA-INDICATED for oral solution; no contra-indication for tablets
– Take with meals.
– The oral solution has a bitter taste.
– Storage: below 25 °C - -
Do not refrigerate or freeze the oral solution.