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     Last updated: November 2022


    Prescription under medical supervision


    Therapeutic action

    • Antiretroviral, inhibitor of HIV integrase


    • HIV infection, in combination with other antiretrovirals 

    Forms and strengths

    • 10 mg dispersible tablet 
    • 50 mg tablet


    The daily dose is administered once daily.

    • Child 1 month and over and adult:


    Weight Daily dose Tablets 

    3 to < 6 kg 

    5 mg

    ½ disp tab 10 mg

    6 to < 10 kg 

    15 mg

    1 ½ disp tab 10 mg

    10 to < 14 kg 

    20 mg

    2 disp tab 10 mg

    14 to < 20 kg 

    25 mg

    2 ½ disp tab 10 mg

    ≥ 20 kg

    30 mg

    or 50 mg

    3 disp tab 10 mg

    or 1 tab 50 mg



    • Depending on the efficacy and tolerance of dolutegravir.

    Contra-indications, adverse effects, precautions

    • Administer with caution to patients with severe hepatic impairment or coinfection with hepatitis B or hepatitis C virus.
    • May cause: 
      • insomnia, depression, anxiety, dizziness, headache, skin rash, gastrointestinal disturbances (nausea, vomiting, diarrhoea, etc.); 
      • rarely: hepatotoxicity, hypersensitivity reactions. 
    • Do not administer simultaneously with antacids (aluminium or magnesium hydroxide, etc.), ferrous salts, calcium and zinc salts (effect of dolutegravir decreased). Take these drugs at least 6 hours before or 2 hours after dolutegravir.
    • In patients taking:
      • metformin: monitor closely blood glucose level and renal function and adjust dose as needed (effect of metformin increased). Do not exceed 1 g of metformin daily.
      • enzyme-inducing drug (e.g. rifampicin, carbamazepine, phenytoin, phenobarbital, efavirenz, nevirapine): double the daily dose of dolutegravir (effect of dolutegravir decreased), e.g. 30 mg 2 times daily rather than 30 mg once daily, and maintain the double dose for 2 weeks after enzyme-inducing drug treatment completion. 
    • In adolescents and women of childbearing age, offer hormonal contraception or an intrauterine device.
    • Pregnancy: small increased risk of neural tube defects but the benefits outweigh the risks. The administration of folic acid during the first trimester may reduce this risk.


    • Three 10 mg dispersible tablets are equivalent to one 50 mg tablet.
    • In children 20 kg and over, preferably use 50 mg tablet unless they cannot swallow tablets.
    • Do not cut, crush or chew dispersible tablets. They can be swallowed or dispersed in a small amount of water.
    • Dolutegravir is also used for HIV post-exposure prophylaxis in combination with other antiretrovirals.
    • Also comes in fixed-dose combination (tenofovir 300 mg/lamivudine 300 mg/dolutegravir 50 mg). Preferably use this formulation when available in adolescents 30 kg and over and adults. In patients taking enzyme-inducing drugs, administer the fixed-dose combination in the morning and dolutegravir 50 mg in the evening.


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