DOXYCYCLINE oral

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    Prescription under medical supervision

     

    Therapeutic action

    • Cycline antibacterial

    Indications

    • Cholera, louse-borne and tick-borne relapsing fevers, epidemic typhus and other rickettsioses, bubonic plague, brucellosis, leptospirosis, lymphogranuloma venereum
    • Lymphatic filariasis, alternative to ivermectin in onchocerciasis
    • Alternative to first-line treatments of treponematosis, atypical pneumonia (Mycoplasma pneumoniae, Chlamydophila pneumoniae), cervicitis and urethritis due to Chlamydia trachomatis (in combination with a treatment for gonorrhoea), donovanosis, syphilis, uncomplicated cutaneous anthrax (if antibiotic therapy is indicated)

    Forms and strengths

    • 100 mg tablet

    Dosage

    Louse-borne relapsing fever, epidemic typhus, cholera

    • Child under 8 years: 4 mg/kg (max. 100 mg) single dose 
    • Child 8 years and over: 100 mg single dose
    • Adult: 200 mg (300 mg in cholera) single dose

     

    Other indications

    • Child 8 years and over: 50 mg 2 times daily or 100 mg once daily (up to 100 mg 2 times daily in severe infections); 1 to 2 mg/kg 2 times daily (max. 100 mg per dose) in brucellosis and leptospirosis
    • Adult: 100 mg 2 times daily or 200 mg once daily 

    Duration

    • Tick-borne relapsing fever, leptospirosis, rickettsiosis, cervicitis and urethritis due to C. trachomatis: 7 days
    • Cutaneous anthrax: 7-10 days
    • Bubonic plague: 10 days
    • Atypical pneumonia: 10-14 days
    • Early syphilis, bejel, pinta, lymphogranuloma: 14 days
    • Filariasis: minimum 4 weeks
    • Late latent syphilis: 30 days
    • Brucellosis: 6 weeks
    • Donovanosis: until complete healing of lesions.

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with allergy to cyclines and to children under 8 years (may damage teeth) except for single dose treatment.
    • Administer with caution to patients with hepatic or renal impairment.
    • May cause: gastrointestinal disturbances, allergic reactions, photosensitivity (protect exposed skin from sun exposure), oesophageal ulcerations (take tablets during meals with a glass of water in an upright position and at least 1 hour before going to bed).
    • Do not give simultaneously with ferrous salts, zinc sulfate, calcium carbonate, antiacids (aluminium/magnesium hydroxide, etc.): administer 2 hours apart.
    • Monitor combination with hepatic enzyme inducers: rifampicin, phenobarbital, phenytoin, carbamazepine, etc. (reduction of the doxycycline efficacy).
    • Pregnancy: CONTRA-INDICATED during the 2nd and 3rd trimester (except for single dose treatment)
    • Breast-feeding: avoid (risk of infant teeth discoloration)

    Storage

     
     
    - Below 25 °C