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- Cycline antibacterial
- Cholera, louse-borne and tick-borne relapsing fevers, epidemic typhus and other rickettsioses, bubonic plague, brucellosis, leptospirosis, lymphogranuloma venereum
- Lymphatic filariasis, alternative to ivermectin in onchocerciasis
- Alternative to first-line treatments of treponematosis, atypical pneumonia (Mycoplasma pneumoniae, Chlamydophila pneumoniae), cervicitis and urethritis due to Chlamydia trachomatis (in combination with a treatment for gonorrhoea), donovanosis, syphilis, uncomplicated cutaneous anthrax (if antibiotic therapy is indicated)
Forms and strengths
- 100 mg tablet
Louse-borne relapsing fever, epidemic typhus, cholera
- Child under 8 years: 4 mg/kg (max. 100 mg) single dose
- Child 8 years and over: 100 mg single dose
- Adult: 200 mg (300 mg in cholera) single dose
- Child 8 years and over: 50 mg 2 times daily or 100 mg once daily (up to 100 mg 2 times daily in severe infections); 1 to 2 mg/kg 2 times daily (max. 100 mg per dose) in brucellosis and leptospirosis
- Adult: 100 mg 2 times daily or 200 mg once daily
- Tick-borne relapsing fever, leptospirosis, rickettsiosis, cervicitis and urethritis due to C. trachomatis: 7 days
- Cutaneous anthrax: 7-10 days
- Bubonic plague: 10 days
- Atypical pneumonia: 10-14 days
- Early syphilis, bejel, pinta, lymphogranuloma: 14 days
- Filariasis: minimum 4 weeks
- Late latent syphilis: 30 days
- Brucellosis: 6 weeks
- Donovanosis: until complete healing of lesions.
Contra-indications, adverse effects, precautions
- Do not administer to patients with allergy to cyclines and to children under 8 years (may damage teeth) except for single dose treatment.
- Administer with caution to patients with hepatic or renal impairment.
- May cause: gastrointestinal disturbances, allergic reactions, photosensitivity (protect exposed skin from sun exposure), oesophageal ulcerations (take tablets during meals with a glass of water in an upright position and at least 1 hour before going to bed).
- Do not give simultaneously with ferrous salts, zinc sulfate, calcium carbonate, antiacids (aluminium/magnesium hydroxide, etc.): administer 2 hours apart.
- Monitor combination with hepatic enzyme inducers: rifampicin, phenobarbital, phenytoin, carbamazepine, etc. (reduction of the doxycycline efficacy).
- Pregnancy: CONTRA-INDICATED during the 2nd and 3rd trimester (except for single dose treatment)
- Breast-feeding: avoid (risk of infant teeth discoloration)