DOXYCYCLINE oral

Prescription under medical supervision


Therapeutic action

– Cycline antibacterial

Indications

– Cholera, louse-borne and tick-borne relapsing fevers, epidemic typhus and other rickettsioses, bubonic plague, brucellosis, leptospirosis, lymphogranuloma venereum
– Lymphatic filariasis, alternative to ivermectin in onchocerciasis
– Alternative to first-line treatments of treponematosis, atypical pneumonia (Mycoplasma pneumoniae, Chlamydophila pneumoniae), cervicitis and urethritis due to Chlamydia trachomatis (in combination with a treatment for gonorrhoea), donovanosis, syphilis, uncomplicated cutaneous anthrax (if antibiotic therapy is indicated)

Forms and strengths

– 100 mg tablet

Dosage

Louse-borne relapsing fever, epidemic typhus, cholera
Child under 8 years: 4 mg/kg (max. 100 mg) single dose 
Child 8 years and over: 100 mg single dose
Adult: 200 mg (300 mg in cholera) single dose

Other indications
Child 8 years and over: 50 mg 2 times daily or 100 mg once daily (up to 100 mg 2 times daily in severe infections); 1 to 2 mg/kg 2 times daily (max. 100 mg per dose) in brucellosis and leptospirosis
Adult: 100 mg 2 times daily or 200 mg once daily 

Duration

Tick-borne relapsing fever, leptospirosis, rickettsiosis, cervicitis and urethritis due to C. trachomatis: 7 days; cutaneous anthrax: 7-10 days; bubonic plague: 10 days; atypical pneumonia: 10-14 days; early syphilis, bejel, pinta, lymphogranuloma: 14 days; filariasis: minimum 4 weeks; late latent syphilis: 30 days; brucellosis: 6 weeks; donovanosis: until complete healing of lesions.

Contra-indications, adverse effects, precautions

– Do not administer to patients with allergy to cyclines and to children under 8 years (may damage teeth) except for single dose treatment.
– Administer with caution to patients with hepatic or renal impairment.
– May cause: gastrointestinal disturbances, allergic reactions, photosensitivity (protect exposed skin from sun exposure), oesophageal ulcerations (take tablets during meals with a glass of water in an upright position and at least 1 hour before going to bed).
– Do not give simultaneously with ferrous salts, zinc sulfate, calcium carbonate, antiacids (aluminium/magnesium hydroxide, etc.): administer 2 hours apart.
– Monitor combination with hepatic enzyme inducers: rifampicin, phenobarbital, phenytoin, carbamazepine, etc. (reduction of the doxycycline efficacy).
Pregnancy: CONTRA-INDICATED during the 2nd and 3rd trimester (except for single dose treatment)
Breast-feeding: avoid (risk of infant teeth discoloration)

Remarks

  Storage: below 25 °C -  -