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Last updated: June 2025
- Long-acting penicillin antibacterial (12 to 24 hours)
Indications
- Diphtheria, when oral treatment is not possible
- Congenital syphilis, if the neonate has clinical signs of syphilis or the mother did not receive adequate treatment for syphilis during pregnancy
Forms and strengths, route of administration
- Powder for injection in vials of:
- 0.6 MIU (600 mg)
vial, to be dissolved with the diluent supplied by the manufacturer (4 ml-ampoule of water for injection) - 1.2 MIU (1.2 g)
vial, to be dissolved with the diluent supplied by the manufacturer (5 ml-ampoule of water for injection)
- 0.6 MIU (600 mg)
- For IM injection only. NEVER ADMINISTER BY IV INJECTION OR INFUSION.
Dosage
Diphtheria
- Child: 50 000 IU/kg (
=50 mg/kg) once daily (max. 1.2 MIU=or 1.2 g daily) - Adult: 1.2 MIU (
=1.2 g) once daily
Congenital syphilis
- Neonate: 50 000 IU/kg (
=50 mg/kg) once daily
Duration
- Diphtheria: change to an oral treatment as soon as the patient can swallow, to complete 14 days of treatment
- Congenital syphilis: 10 days
Contra-indications, adverse effects, precautions
- Do not administer to patients allergic to penicillin and/or procaine.
- Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur) or with renal impairment.
- May cause:
- gastrointestinal disturbances;
- allergic reactions sometimes severe. In the event of allergic reactions, stop treatment immediately.
- Ensure that the needle does not accidentally enter a vessel (risk of serious neurovascular damage).
- Pregnancy and breast-feeding: no contra-indication
Remarks
- Also comes in 1 MIU,
and3 MIU and 4 MIU vials of powder for injection. - Do not confuse procaine benzylpenicillin with short-acting benzylpenicillin (penicillin G), administered several times per day by IV route.
- Do not mix with other drugs in the same syringe.
Storage
– Below 25 °C
Once reconstituted, suspension must be used immediately.
Once reconstituted, suspension must be used immediately.