BENZYLPENICILLIN PROCAINE = PENICILLIN G PROCAINE injectable

Select language:
On this page

     

    Last updated: January 2021

     

    Prescription under medical supervision


    Therapeutic action

    • Long-acting penicillin antibacterial (12 to 24 hours)

    Indications

    • Diphtheria, when oral treatment is not possible
    • Congenital syphilis, if the neonate has clinical signs of syphilis or the mother did not receive adequate treatment for syphilis during pregnancy

    Forms and strengths, route of administration

    • Powder for injection in:
      • 0.6 MIU vial, to be dissolved with the diluent supplied by the manufacturer (4 ml-ampoule of water for injection)
      • 1.2 MIU vial, to be dissolved with the diluent supplied by the manufacturer (5 ml-ampoule of water for injection)
    • For IM injection only. NEVER ADMINISTER BY IV INJECTION OR INFUSION.

    Dosage

    Diphtheria

    • Child: 50 000 IU/kg (= 50 mg/kg) once daily (max. 1.2 MIU = 1.2 g daily)
    • Adult: 1.2 MIU (= 1.2 g) once daily 

     

    Congenital syphilis

    • Neonate: 50 000 IU/kg (= 50 mg/kg) once daily 

    Duration

    • Diphtheria: change to an oral treatment as soon as the patient can swallow, to complete 14 days of treatment
    • Congenital syphilis: 10 days

    Contra-indications, adverse effects, precautions

    • Do not administer to patients allergic to penicillin and/or procaine.
    • Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur) or with renal impairment.
    • May cause:
      • gastrointestinal disturbances;
      • allergic reactions sometimes severe. In the event of allergic reactions, stop treatment immediately.
    • Ensure that the needle does not accidentally enter a vessel (risk of serious neurovascular damage).
    • Pregnancy and breast-feeding: no contra-indication

    Remarks

    • Also comes in 1 MIU and 3 MIU vials of powder for injection.
    • Do not confuse procaine benzylpenicillin with short-acting benzylpenicillin (penicillin G), administered several times per day by IV route.
    • Do not mix with other drugs in the same syringe.

    Storage

     
    – Below 25 °C 
    Once reconstituted, suspension must be used immediately.