KETAMINE injectable

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    Prescription under medical supervision

     

    Therapeutic action

    • General anaesthetic

    Indications

    • Induction and maintenance of general anaesthesia

    Forms and strengths, route of administration

    • 250 mg in 5 ml ampoule (50 mg/ml) for IM, IV injection or infusion

    Dosage

    Child and adult:

    • Induction
      • IV: 2 mg/kg to be injected slowly. Anaesthesia is produced within one minute and lasts 10 to 15 minutes.
      • IM: 8 to 10 mg/kg. Anaesthesia is produced within 5 minutes and lasts 15 to 30 minutes.
    • Maintenance
      • IV: 0.5 to 1 mg/kg depending on recovery signs (approximately every 15 minutes)
      • IM: 5 mg/kg approximately every 20 to 30 minutes

    Duration

    • Depending on duration of the operation

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with intraocular hypertension, pre-eclampsia.
    • Administer with caution to patients with arterial or intracranial hypertension, coronary insufficiency, psychiatric disorders.
    • May cause: hypertension, hypersalivation, hallucinations during recovery (less frequent in children or when injected IM), apnoea following rapid IV injection.
    • Premedication to prevent hypersalivation and hallucinations:
      • atropine IV: 0.01 to 0.015 mg/kg + diazepam slow IV: 0.1 mg/kg, during induction

    or

    • atropine IM: 0.01 to 0.015 mg/kg + diazepam IM: 0.1 mg/kg, 30 minutes before induction
    • Technical equipment for intubation and ventilation must be available and ready for use.
    • Pregnancy: no contra-indication, except in pre-eclampsia. For ceaserean sections, do not exceed 1 mg/kg by IV injection (risk of neonatal respiratory depression at higher doses).
    • Breast-feeding: no contra-indication

    Remarks

    • Ketamine has no muscle relaxant properties.
    • In some countries, ketamine is on the list of narcotics: follow national regulations.
    • Also comes in 10 ml ampoule containing 500 mg (50 mg/ml).

    Storage

     
    –  Below 25 °C