PARACETAMOL = ACETAMINOPHEN injectable

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    Prescription under medical supervision

     

    Therapeutic action

    • Analgesic, antipyretic

    Indications

    • Very high fever, only when oral administration is not possible
    • Mild pain, only when oral administration is not possible

    Forms and strengths, route of administration

    • 500 mg (10 mg/ml, 50 ml) and 1 g (10 mg/ml, 100 ml) vials, for infusion

    Dosage

    • Neonate: 7.5 mg/kg (0.75 ml/kg) every 6 hours, to be administered over 15 minutes (max. 30 mg/kg daily)
    • Child ≥ 1 month and < 10 kg: 10 mg/kg (1 ml/kg) every 6 hours, to be administered over 15 minutes (max. 30 mg/kg daily)
    • Patient ≥ 10 kg and < 50 kg: 15 mg/kg (1.5 ml/kg) every 6 hours, to be administered over 15 minutes (max. 60 mg/kg daily)
    • Patient ≥ 50 kg: 1 g (100 ml) every 6 hours, to be administered over 15 minutes (max. 4 g daily)

    Duration

    • According to clinical response.

    Change to oral route as soon as possible.

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with severe hepatic impairment.
    • Administer with caution to patients with moderate hepatic impairment, severe renal impairment, chronic alcoholism, malnutrition, dehydration.
    • May cause (very rarely): malaise, hypotension and rash.
    • Do not exceed indicated doses, especially in children and elderly patients. Paracetamol intoxications are severe (hepatic cytolysis).
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication

    Remarks

    • As the efficacy of IV paracetamol is not superior to the efficacy of oral paracetamol, the IV route is restricted to situations where oral administration is not possible.
    • For mild pain, IV paracetamol is used alone or in combination with an NSAID administered parenterally.
    • For moderate pain, IV paracetamol is used in combination with an NSAID and tramadol administered parenterally.
    • For severe pain, IV paracetamol is used in combination with an NSAID and morphine administered parenterally.
    • Paracetamol has no anti-inflammatory properties.
    • Do not mix with other drugs in the same infusion bottle.

    Storage

     
    – Below 25 °C