ONDANSETRON injectable

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    Prescription under medical supervision

     

    Therapeutic action

    • Antiemetic (serotonin 5-HT3 receptor antagonist)

    Indications

    • Prevention of post-operative nausea and vomiting in children
    • Treatment of post-operative nausea and vomiting

    Forms and strengths, route of administration

    • 4 mg ampoule (2 mg/ml, 2 ml) for slow IV injection (3 to 5 minutes)

    Dosage and duration

    Prevention of post-operative nausea and vomiting

    • Child over 1 month: 0.1 mg/kg at the end of surgery (max. 4 mg per injection)

     

    Treatment of nausea and vomiting

    • Child over 1 month:
      • No prophylactic dose of ondansetron received: 0.1 mg/kg every 8 hours if necessary
      • Prophylactic dose of ondansetron received and late postoperative vomiting (≥ 6 hours after surgery): 0.1 mg/kg every 6 hours if necessary

    Do not exceed 4 mg per injection and 3 injections per 24 hours.

    • Adult: 4 mg every 8 hours if necessary (max. 3 injections per 24 hours)

    Contra-indications, adverse effects, precautions

    • Do not administer to children less than 1 month of age.
    • Administer with caution and monitor use in patients with congenital long QT syndrome, cardiac insufficiency and bradycardia.
    • Reduce the dose in patients with hepatic failure (max. 8 mg daily).
    • May cause: headache, sensation of flushing or warmth, hiccups, constipation, heart rhythm disorders, QT interval prolongation, extrapyramidal reactions, seizures, cutaneous allergic reactions (Lyell’s and Stevens-johnson syndromes).
    • Avoid or monitor combination with:
      • drugs that prolong the QT interval: amiodarone, bedaquilline, chloroquine, co-artemether, erythromycin, fluconazole, haloperidol, moxifloxacin, mefloquine, pentamidine, quinine, etc.;
      • serotonergics: fluoxetine, paroxetine, tricyclic antidepressants, etc.;
      • enzyme inducers: rifampicin, rifabutin, nevirapine, ritonavir, phenobarbital, phenytoin, carbamazepine, griseofulvin, etc. (efficacy of ondansetron reduced);
      • tramadol (antalgic effect reduced).
    • Pregnancy: avoid during the first trimester; not recommended for nausea and vomiting of pregnancy
    • Breast-feeding: not recommended

    Storage

     
    – Below 25 °C