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    Last updated: March 2024


    Prescription under medical supervision


    Therapeutic action

    • Vitamin, anti-haemorrhagic


    • Prophylaxis and treatment of haemorrhagic disease of the newborn

    Forms and strengths, route of administration

    • 2 mg ampoule (10 mg/ml, 0.2 ml), for oral administration, IM or slow IV injection


    Prophylaxis of haemorrhagic disease of the newborn
    By IM route, the day of birth:

    • Neonate < 1.5 kg: 0.5 mg single dose
    • Neonate ≥ 1.5 kg: 1 mg single dose


    Treatment of haemorrhagic disease of the newborn
    By IM or slow IV route:
    1 mg every 8 hours if necessary, depending on clinical evolution and coagulation tests results

    Contra-indications, adverse effects, precautions

    • May cause: allergic reactions, especially by IV route; haematoma at IM injection site.
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication


    • Also comes in 10 mg ampoules (10 mg/ml, 1 ml) for use in adults only (treatment of haemorrhage due to antivitamin K agents, etc.) .
    • Vitamin K1 is also used as prophylaxis for neonatal hypoprothrombinemia in mothers treated with enzyme-inducing antituberculosis drugs (rifampicin, rifabutin) during pregnancy. Use 10 mg ampoules (10 mg/ml, 1 ml): administer 10 mg/day of vitamin K1 by oral route for 15 days before birth. This maternal prevention does not change the need for IM administration of vitamin K1 in neonates. 
    • Do not dilute or mix with other drugs in the same syringe.


    –  Below 25 °C