METOCLOPRAMIDE injectable

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    Prescription under medical supervision

     

    Therapeutic action

    • Antiemetic (dopamine antagonist)

    Indications

    • Prevention or symptomatic treatment of nausea and vomiting in adults

    Forms and strengths, route of administration

    • 10 mg in 2 ml ampoule (5 mg/ml) for IM or slow IV injection (3 to 5 minutes)

    Dosage

    • Adult: 10 mg every 8 hours if necessary

    Duration

    • According to clinical evolution, as short as possible

    Contra-indications, adverse effects, precautions

    • Do not administer to children < 18 years and to patients with gastrointestinal haemorrhage, obstruction or perforation.
    • Reduce the dose by half in patients with severe renal impairment.
    • Administer with caution and monitor use in patients > 60 years and patients with epilepsy or Parkinson's disease.
    • May cause: drowsiness, dizziness, confusion, extrapyramidal symptoms, seizures (especially in epileptics), allergic reactions, cardiac disorders (hypotension, bradycardia, cardiac arrest); neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular disorders), rare but requiring immediate treatment discontinuation.
    • Do not combine with levodopa (antagonism).
    • Avoid combination with CNS depressants (opioid analgesics, antipsychotics, sedatives, antidepressants, antihistamines, etc.) and antihypertensive drugs (increased risk of hypotension).
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication

    Remarks

    • For postoperative nausea and vomiting in adults, efficacy of metoclopramide is limited: ondansetron is preferred.
    • Metoclopramide is also used as a gastrointestinal prokinetic agent in patients receiving enteral feeding by a nasogastric tube in intensive care units.

    Storage

     
    – Below 25 °C