DEXAMETHASONE injectable

Select language:
On this page

     

    Prescription under medical supervision

     

    Therapeutic action

    • Corticosteroid

    Indications

    • Inflammatory syndrome in severe infections: severe typhoid fever, acute subglottic laryngitis, etc.
    • Foetal lung maturation, in the event of threatened premature delivery before 34 weeks of gestation

    Forms and strengths, route of administration

    • 4 mg dexamethasone phosphate in 1 ml ampoule (4 mg/ml) for IM or IV injection or infusion

    Dosage and duration

    Inflammatory syndrome in severe infections
    Dosage and duration vary according to severity and clinical response:

    • Child: 0.2 to 0.4 mg/kg daily
    • Adult: initial dose of 0.5 to 24 mg daily

     

    Foetal lung maturation

    • Administer to the mother: 6 mg by IM injection every 12 hours for 2 days (total dose: 24 mg)

    Contra-indications, adverse effects, precautions

    • For systemic infections, only administer if patient is under antibiotic treatment.
    • In the event of treatment longer than 10 days, decrease doses gradually to avoid adrenal gland failure.
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication

    Remarks

    • Foetal lung maturation:
      • after 34 weeks of gestation, corticosteroid treatment is not indicated;
      • dexamethasone may be replaced by betamethasone: 2 doses of 12 mg by IM injection at 24-hour interval (total dose: 24 mg).
    • For allergic reactions (Quinke’s oedema, anaphylactic shock) and status asthmaticus, use hydrocortisone.
    • Dexamethasone acetate, insoluble in water, is a suspension used only for local treatment: intra-articular or peri-articular injection, epidural injection (sciatica).

    Storage

     
     - Below 25 °C 
    The solution precipitates at 0 °C, it must not be exposed to cold temperatures.