METRONIDAZOLE injectable

Select language:
On this page

     

    Prescription under medical supervision

     

    Therapeutic action

    • Antiprotozoal, antibacterial

    Indications

    • Severe infections due to anaerobic bacteria (Bacteroides sp, Clostridium sp, etc.)

    Forms and strengths, route of administration

    • 500 mg in 100 ml vial or bag (5 mg/ml), for infusion, to be administered over 30 minutes

    Dosage

    • Child 1 month and over: 10 mg/kg every 8 hours (max. 1500 mg daily)
    • Adult: 500 mg every 8 hours

    Duration

    • According to indication.

    Change to oral treatment as soon as possible.

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with allergy to metronidazole or another nitroimidazole (tinidazole, secnidazole, etc.).
    • Do not drink alcohol during treatment (antabuse reaction).
    • May cause: gastrointestinal disturbances, brownish urine, allergic reactions, headache, dizziness.
    • Monitor combination with anticoagulants (increased risk of haemorrhage), lithium, phenytoin and ergometrine (increased plasma concentrations of these drugs).
    • Administer with caution, reduce total daily dose to ⅓ and give once daily to patients with severe hepatic impairment.
    • Pregnancy: no contra-indication
    • Breast-feeding: avoid (significantly excreted in milk)

    Remarks

    • Metronidazole is as effective by oral route as by parenteral route.
    • Do not add any drug in the infusion vial.

    Storage

     
    –  Below 25 °C