THIAMINE = VITAMIN B1 injectable

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    Last updated: August 2021

     

    Prescription under medical supervision

     

    Therapeutic action

    • Vitamin

    Indications

    • Initial treatment of severe thiamine (vitamin B1) deficiency: severe acute forms of beriberi, neurological complications of chronic alcoholism (delirium tremens, Wernicke’s encephalopathy)

    Forms and strengths, route of administration

    • 100 mg thiamine hydrochloride in 2 ml ampoule (50 mg/ml) for IM or very slow IV route (30 minutes)

    Dosage and duration

    Infantile beriberi
    25 mg by IV route then, 25 mg by IM route once or 2 times daily then, change to oral route (10 mg once daily) as soon as symptoms have improved.

     

    Acute beriberi
    50 mg by IM route then change to oral route (50 mg 3 times daily until symptoms improve then, 10 mg once daily)
    or, depending on severity, 50 mg by IM route every 8 hours for a few days then change to oral route (10 mg once daily).

     

    Delirium tremens, Wernicke’s encephalopathy
    100 mg by IM or IV route 3 times daily for 3 to 5 days

    Contra-indications, adverse effects, precautions

    • May cause: hypotension; anaphylactic reaction, especially when injected IV (inject very slowly over 30 minutes).
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication

    Remarks

    • Thiamine is also called aneurine.
    • Injectable thiamine is not included in the WHO list of essential medicines.

    Storage

     
    – Below 25 °C