STREPTOMYCIN injectable

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    Prescription under medical supervision

     

    Therapeutic action

    • Antibacterial  (group of aminoglycosides)

    Indications

    • Plague
    • Brucellosis, in combination with doxycycline

    Forms and strengths, route of administration

    • Powder for injection, vial containing 1 g of streptomycin base, to be dissolved in 4 ml of water for injection, for IM injection.
      DO NOT ADMINISTER BY IV INJECTION.

    Dosage

    Plague

    • Child: 15 mg/kg every 12 hours (max. 2 g daily)
    • Adult: 1 g every 12 hours

     

    Brucellosis

    • Adult: 1 g once daily

    Duration

    • Plague: 10 days
    • Brucellosis: 2 weeks

    Contra-indications, adverse effects, precautions

    • Do not administer in patients with allergy to aminoglycosides.
    • Administer with caution to patients with history of renal, vestibular or auditory problems.
    • Reduce the dose in patients with renal impairment.
    • May cause: ototoxicity (vestibular and auditory damage), nephrotoxicity, neuropathy, neuromuscular blockade; rarely, allergic reactions.
    • Stop treatment in the event of dizziness, paraesthesia, tinnitus or hearing defects (ototoxicity).
    • Drink sufficient liquid to limit the risk of renal toxicity.
    • Avoid or monitor combination with other ototoxic (e.g. quinine) or nephrotoxic drugs (e.g. other aminoglycosides, amphotericin B, pentamidine).
    • Pregnancy: CONTRA-INDICATED
    • Breast-feeding: no contra-indication

    Remarks

    • The volume of suspension obtained after reconstitution of 1 g of powder in 4 ml of water for injection is 4.83 ml and not 4 ml. The concentration of the suspension is 207 mg/ml and not 250 mg/ml.

    Storage

     
    –  Below 25 °C