ATROPINE injectable

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    Prescription under medical supervision

     

    Therapeutic action

    Parasympatholytic, antispasmodic

    Indications

    • Premedication in anaesthesia
    • Spasms of the gastrointestinal tract
    • Organophosphorus pesticide poisoning

    Forms and strengths, route of administration

    • 1 mg atropine sulfate in 1 ml ampoule (1 mg/ml) for SC, IM, IV injection
    • Also comes in 0.25 mg/ml and 0.5 mg/ml ampoules.

    Dosage

    Premedication in anaesthesia

    • Child: 0.01 to 0.02 mg/kg by SC or IV injection
    • Adult: 1 mg by SC or IV injection

     

    Spasms of the gastrointestinal tract

    • Child from 2 to 6 years: 0.25 mg by SC injection, single dose
    • Child over 6 years: 0.5 mg by SC injection, single dose
    • Adult: 0.25 to 1 mg by SC injection, every 6 hours if necessary (max. 2 mg daily)

     

    Organophosphorus pesticide poisoning

    • Child: 0.02 to 0.05 mg/kg by IM or slow IV injection
    • Adult: 2 mg by IM or slow IV injection

     

    Repeat every 5 to 10 minutes until signs of atropinisation appear (reduced secretions, tachycardia, dilatation of the pupils).

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with urethro-prostatic disorders, cardiac disorders, glaucoma.
    • Do not administer to children with high fever.
    • May cause: urinary retention, dryness of the mouth, constipation, dizziness, headache, dilatation of the pupils, tachycardia.
    • Administer with caution and under close supervision to patients taking other anti cholinergic drugs (antidepressants, neuroleptics, H1 antihistamines, antiparkinsonians, etc.).
    • Pregnancy: no contra-indication; NO PROLONGED TREATMENT
    • Breast-feeding: avoid; NO PROLONGED TREATMENT

    Remarks

    • Atropine IV is also used to prevent bradycardic effects of neostigmine when used to reverse the effects of competitive muscle relaxants: 0.02 mg/kg in children; 1 mg in adults.
    • Do not mix with other drugs in the same syringe.

    Storage

     
    – Below 25 °C