OMEPRAZOLE injectable

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    Prescription under medical supervision


    Therapeutic action

    • Antiulcer drug (proton pump inhibitor)


    • Peptic ulcer perforation

    Forms and strengths, route of administration

    • Powder for injection, 40 mg vial, to be dissolved in 100 ml of 0.9% sodium chloride or 5% glucose, for IV infusion


    • Adult: 40 mg once daily to be administered over 20 to 30 minutes


    • Change to oral treatment as soon as the patient can eat.

    Contra-indications, adverse effects, precautions

    • May cause: headache, diarrhoea, skin rash, nausea, abdominal pain, dizziness.
    • Avoid combination with itraconazole and ketoconazole (decreases efficacy of these drugs).
    • Monitor combination with warfarin, digoxin, phenytoin.
    • Do not exceed 20 mg daily in patients with severe hepatic impairment.
    • Pregnancy: no contra-indication
    • Breast-feeding: avoid, administer only if clearly need


    • Only use 0.9% sodium chloride or 5% glucose for dilution.
    • Injectable omeprazole is not included in the WHO list of essential medicines.


    – Below 25 °C