OMEPRAZOLE injectable

Therapeutic action

• Antiulcer drug (proton pump inhibitor)

Indications

• Peptic ulcer perforation

Forms and strengths, route of administration

• Powder for injection, 40 mg vial, to be dissolved in 100 ml of 0.9% sodium chloride or 5% glucose, for IV infusion

Dosage

• Adult: 40 mg once daily to be administered over 20 to 30 minutes

Duration

• Change to oral treatment as soon as the patient can eat.

Contra-indications, adverse effects, precautions

• May cause: headache, diarrhoea, skin rash, nausea, abdominal pain, dizziness.
• Avoid combination with itraconazole and ketoconazole (decreases efficacy of these drugs).
• Monitor combination with warfarin, digoxin, phenytoin.
• Do not exceed 20 mg daily in patients with severe hepatic impairment.
• Pregnancy: no contra-indication
• Breast-feeding: avoid, administer only if clearly need

Remarks

• Only use 0.9% sodium chloride or 5% glucose for dilution.
• Injectable omeprazole is not included in the WHO list of essential medicines.

Storage