CHLORAMPHENICOL injectable

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    Last updated: September 2022

     

    Prescription under medical supervision

     

    Therapeutic action

    • Phenicol antibacterial

    Indications

    • Plague meningitis

    Forms and strengths, route of administration

    • 1 g powder for injection, to be dissolved in 10 ml of water for injection, for IV injection over 1 to 2 minutes

    Dosage and duration

    • Child 1 to 12 years: 25 mg/kg every 8 hours for 10 to 14 days
    • Child 13 years and over and adult: 1 g every 8 hours for 10 to 14 days

     

    Age

    Weight

    1 g vial
    (to be dissolved in 10 ml)

    1 to < 2 years

    10 to < 13 kg

    3 ml x 3

    2 to < 3 years

    13 to < 15 kg

    3.5 ml x 3

    3 to < 6 years

    15 to < 20 kg

    5 ml x 3

    6 to < 8 years

    20 to < 25 kg

    6 ml x 3

    8 to < 9 years

    25 to < 30 kg

    7 ml x 3

    9 to < 11 years

    30 to < 35 kg

    8 ml x 3

    11 to < 13 years

    35 to < 45 kg

    9 ml x 3

    ≥ 13 years and adult

    ≥ 45 kg

    10 ml x 3

     

    Contra-indications, adverse effects, precautions

    • Do not administer to children under 1 year.
    • Do not administer to patients with:
      • history of allergic reaction or bone marrow depression during a previous treatment with chloramphenicol;
      • G6PD deficiency.
    • May cause:
      • dose-related haematological toxicity (bone marrow depression, anaemia, leucopenia, thrombocytopenia), allergic reactions. In these events, stop treatment immediately;
      • gastrointestinal disturbances, peripheral and optic neuropathies.
    • Reduce dosage in patients with hepatic or renal impairment.
    • Avoid or monitor combination with potentially haematotoxic drugs (carbamazepine, co-trimoxazole, flucytocine, pyrimethamine, zidovudine, etc.).
    • Pregnancy and breast-feeding: no contra-indication for plague meningitis.
      • If used during the 3rd trimester of pregancy, risk of grey syndrome in the neonate (vomiting, hypothermia, blue-grey skin colour and cardiovascular depression). 
      • If used during breast-feeding, monitor neonate for haematological disorders and gastrointestinal disturbances.

    Storage

     
    –  Below 25 °C