CLINDAMYCIN injectable

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    Last updated: September 2022

     

     
    Prescription under medical supervision

     

    Therapeutic action

    • Lincosamide antibacterial

    Indications

    • Second-line treatment of severe staphylococcal and/or streptococcal infections (e.g. cellulitis, erysipelas, pneumonia)
    • Necrotizing skin and soft tissues infections (necrotizing fasciitis, gas gangrene, etc.), severe cutaneous anthrax, in combination with other antibacterials

    Forms and strengths, route of administration

    • 300 mg ampoule (150 mg/ml, 2 ml), for IV infusion in 0.9% sodium chloride or 5% glucose, to be administered over 30 minutes.
    • NEVER USE BY DIRECT UNDILUTED IV.

    Dosage

    Severe staphylococcal and/or streptococcal infections

    • Neonate 0 to 7 days (< 2 kg): 5 mg/kg every 12 hours
    • Neonate 0 to 7 days (≥ 2 kg): 5 mg/kg every 8 hours
    • Neonate 8 days to < 1 month (< 2 kg): 5 mg/kg every 8 hours
    • Neonate 8 days to < 1 month (≥ 2 kg): 10 mg/kg every 8 hours
    • Child 1 month and over: 10 mg/kg (max. 600 mg) every 8 hours
    • Adult: 600 mg every 8 hours

     

    Necrotizing infections, severe cutaneous anthrax

    • Neonate: as above
    • Child 1 month and over: 10 to 13 mg/kg (max. 900 mg) every 8 hours
    • Adult: 900 mg every 8 hours

     

    Dilute each dose of clindamycin in 5 ml/kg of 0.9% sodium chloride or 5% glucose in children less than 20 kg and in a bag of 100 ml of 0.9% sodium chloride or 5% glucose in children 20 kg and over and in adults.

    Duration

    • Cellulitis, erysipelas: 7 to 10 days
    • Pneumonia: 10 to 14 days
    • Severe cutaneous anthrax: 14 days
    • Necrotizing infections: according to clinical evolution

     

    Change to oral route as soon as possible.

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with allergy to lincosamides or history of pseudomembranous colitis.
    • Reduce dosage in patients with hepatic impairment.
    • May cause: pseudomembranous colitis, rash, jaundice, severe allergic reactions. In these cases, stop treatment.
    • In the event of pseudomembranous colitis, treat for Clostridium difficile infection (oral metronidazole).
    • Pregnancy: no contra-indication
    • Breast-feeding: use only when there are no therapeutic alternative. Check child's stools (risk of pseudomembranous colitis).

    Remarks

    • Do not mix with other drugs in the same infusion bottle.
    • Some formulations contain benzyl alcohol and should not be used in neonates. 

    Storage

     

    –  Below 25 °C