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- Antiulcer drug (proton pump inhibitor)
- Peptic ulcer perforation
Forms and strengths, route of administration
- Powder for injection, 40 mg vial, to be dissolved in 100 ml of 0.9% sodium chloride or 5% glucose, for IV infusion
- Adult: 40 mg once daily to be administered over 20 to 30 minutes
- Change to oral treatment as soon as the patient can eat.
Contra-indications, adverse effects, precautions
- May cause: headache, diarrhoea, skin rash, nausea, abdominal pain, dizziness.
- Avoid combination with itraconazole and ketoconazole (decreases efficacy of these drugs).
- Monitor combination with warfarin, digoxin, phenytoin.
- Do not exceed 20 mg daily in patients with severe hepatic impairment.
- Pregnancy: no contra-indication
- Breast-feeding: avoid, administer only if clearly need
- Only use 0.9% sodium chloride or 5% glucose for dilution.
- Injectable omeprazole is not included in the WHO list of essential medicines.
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