AMPICILLIN injectable

Prescription under medical supervision


Therapeutic action

– Penicillin antibacterial

Indications

– Severe bacterial infections: meningitis, pneumonia, pyelonephritis, postpartum upper genital tract infection, etc., in combination with other antibacterials
– Severe typhoid fever if the strain is susceptible (recent drug susceptibility test)

Forms and strengths, route of administration

– Powder for injection, in 500 mg and 1 g vials, to be dissolved in 5 ml of water for injection
– Prefer adminstration by slow IV injection (3 to 5 minutes) or IV infusion (30 minutes) in 0.9% sodium chloride or 5% glucose; use IM route only if correct IV administration is not possible .
– In neonates, administer only by slow IV injection or IV infusion.

Dosage

– Meningitis in young children, in combination with cefotaxime or gentamicin 
• Neonate:
   0 to 7 days (< 2 kg): 100 mg/kg every 12 hours 
   0 to 7 days (≥ 2 kg): 100 mg/kg every 8 hours 
   8 days to < 1 month: 100 mg/kg every 8 hours 
• Child 1 to 3 months: 100 mg/kg every 8 hours 

– Pneumonia and pyelonephritis, in combination with gentamicin
• Neonate 
   0 to 7 days (< 2 kg): 50 mg/kg every 12 hours 
   0 to 7 days (≥ 2 kg): 50 mg/kg every 8 hours 
   8 days to < 1 month: 50 mg/kg every 8 hours 
• Child 1 month and over: 50 mg/kg every 6 to 8 hours 
• Adult: 1 g every 6 or 8 hours (2 g every 6 hours in pyelonephritis) 

 Postpartum upper genital tract infection, in combination with metronidazole and gentamicin
Adult: 2 g every 8 hours 

– Severe typhoid fever 
Child: 50 mg/kg every 6 to 8 hours
Adult: 1 g every 6 to 8 hours

For administration by IV infusion, dilute each dose of ampicillin in 5 ml/kg of 0.9% sodium chloride or 5% glucose in children less than 20 kg and in a bag of 100 ml of 0.9% sodium chloride or 5% glucose in children 20 kg and over and in adults.

Duration

– According to indication and clinical response. Change to oral treatment as soon as possible with amoxicillin or a combination of antibacterials, depending on the indication.

Contra-indications, adverse effects, precautions

– Do not administer to patients with infectious mononucleosis (risk of skin eruption) or to penicillin allergic patients.
– Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur) or patients with severe renal impairment (reduce dosage).
– May cause: skin eruption, gastrointestinal disturbances, allergic reactions sometimes severe.
– Do not combine with methotrexate (increased methotrexate toxicity).
– Pregnancy: no contra-indication
– Breast-feeding: no contra-indication

Remarks

– Do not mix with another drug in the same syringe or infusion.
– Injectable amoxicillin is used for the same indications.
 Storage: below 25 °C - 
Once reconstituted, the solution must be used immediately.