BENZYLPENICILLIN PROCAINE = PENICILLIN G PROCAINE injectable

Last updated: January 2021

Prescription under medical supervision


Therapeutic action

– Long-acting penicillin antibacterial (12 to 24 hours)

Indications

– Diphtheria, when oral treatment is not possible
– Congenital syphilis, if the neonate has clinical signs of syphilis or the mother did not receive adequate treatment for syphilis during pregnancy

Forms and strengths, route of administration

– Powder for injection in:
• 0.6 MIU vial, to be dissolved with the diluent supplied by the manufacturer (4 ml-ampoule of water for injection)
• 1.2 MIU vial, to be dissolved
 with the diluent supplied by the manufacturer (5 ml-ampoule of water for injection)
– For IM injection only. NEVER ADMINISTER BY IV INJECTION OR INFUSION.

Dosage

– Diphtheria
Child: 50 000 IU/kg (= 50 mg/kg) once daily (max. 1.2 MIU = 1.2 g daily)
Adult: 1.2 MIU (= 1.2 g) once daily 

– Congenital syphilis
Neonate: 50 000 IU/kg (= 50 mg/kg) once daily 

Duration

– Diphtheria: change to an oral treatment as soon as the patient can swallow, to complete 14 days of treatment; congenital syphilis: 10 days

Contra-indications, adverse effects, precautions

– Do not administer to patients allergic to penicillin and/or procaine.
– Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur) or with renal impairment.
– May cause:
• gastrointestinal disturbances;
• allergic reactions sometimes severe. In the event of allergic reactions, stop treatment immediately.
– Ensure that the needle does not accidentally enter a vessel (risk of serious neurovascular damage).
Pregnancy and breast-feeding: no contra-indication

Remarks

– Also comes in 1 MIU and 3 MIU vials of powder for injection.
– Do not confuse procaine benzylpenicillin with short-acting benzylpenicillin (penicillin G), administered several times per day by IV route.
– Do not mix with other drugs in the same syringe.
Storage: below 25 °C
Once reconstituted, suspension must be used immediately.