– Rapid-acting pancreatic antidiabetic hormone
– Emergency treatment of hyperglycaemia (diabetic ketoacidosis and hyperosmolar hyperglycaemic state)
Forms and strengths, route of administration
– 1000 IU of insulin in 10 ml vial (100 IU/ml) for deep SC injection (abdomen, thigh, buttock or arm) or IV injection, administered with a syringe calibrated in insulin units for U-100 insulin (100 UI/ml) or IV infusion
Child and adult: one SC injection 15 to 30 minutes before a meal, in combination with intermediate-acting insulin
Dosage must be individualised according to need. Adapt dose in the event of physical activity, change in diet or infection.
– Emergency treatment of hyperglycaemia
Adult: initial dose of 0.1 IU/kg by IV injection then 0.1 IU/kg/hour by continuous IV infusion. Adapt the protocol to blood glucose levels.
Contra-indications, adverse effects, precautions
– See "Insulin: general information".
– In the event of combination with intermediate-acting insulin, always prepare the mix in the syringe immediately before administration and in the following order: first draw the short-acting insulin then the intermediate-acting insulin.
– By IV route, insulin has a very short half-life of around 5 minutes and the effect disappears within 30 minutes of injection.
– Storage: do not freeze -
• Unopened vial: to be kept refrigerated (2 °C to 8 °C)
• Opened vial: max. 4 weeks at below 25 °C and protected from light.