OMEPRAZOLE injectable

Prescription under medical supervision

Therapeutic action

– Antiulcer drug (proton pump inhibitor)


– Peptic ulcer perforation

Forms and strengths, route of administration

– Powder for injection, 40 mg vial, to be dissolved in 100 ml of 0.9% sodium chloride or 5% glucose, for IV infusion


– Adult: 40 mg once daily to be administered over 20 to 30 minutes


– Change to oral treatment as soon as the patient can eat.

Contra-indications, adverse effects, precautions

– May cause: headache, diarrhoea, skin rash, nausea, abdominal pain, dizziness.
– Avoid combination with itraconazole and ketoconazole (decreases efficacy of these drugs).
– Monitor combination with warfarin, digoxin, phenytoin.
– Do not exceed 20 mg daily in patients with severe hepatic impairment.
– Pregnancy: no contra-indication
– Breast-feeding: avoid, administer only if clearly need


– Only use 0.9% sodium chloride or 5% glucose for dilution.
– Injectable omeprazole is not included in the WHO list of essential medicines.
– Storage: below 25 °C -