PARACETAMOL = ACETAMINOPHEN injectable

Prescription under medical supervision


Therapeutic action

– Analgesic, antipyretic

Indications

– Very high fever, only when oral administration is not possible
– Mild pain, only when oral administration is not possible

Forms and strengths, route of administration

– 500 mg (10 mg/ml, 50 ml) and 1 g (10 mg/ml, 100 ml) vials, for infusion

Dosage

– Neonate: 7.5 mg/kg (0.75 ml/kg) every 6 hours, to be administered over 15 minutes (max. 30 mg/kg daily)
– Child ≥ 1 month and < 10 kg: 10 mg/kg (1 ml/kg) every 6 hours, to be administered over 15 minutes (max. 30 mg/kg daily)
– Patient ≥ 10 kg and < 50 kg: 15 mg/kg (1.5 ml/kg) every 6 hours, to be administered over 15 minutes (max. 60 mg/kg daily)
– Patient ≥ 50 kg: 1 g (100 ml) every 6 hours, to be administered over 15 minutes (max. 4 g daily)

Duration

– According to clinical response. Change to oral route as soon as possible.

Contra-indications, adverse effects, precautions

– Do not administer to patients with severe hepatic impairment.
– Administer with caution to patients with moderate hepatic impairment, severe renal impairment, chronic alcoholism, malnutrition, dehydration.
– May cause (very rarely): malaise, hypotension and rash.
– Do not exceed indicated doses, especially in children and elderly patients. Paracetamol intoxications are severe (hepatic cytolysis).
– Pregnancy: no contra-indication
– Breast-feeding: no contra-indication

Remarks

– As the efficacy of IV paracetamol is not superior to the efficacy of oral paracetamol, the IV route is restricted to situations where oral administration is not possible.
– For mild pain, IV paracetamol is used alone or in combination with an NSAID administered parenterally.
– For moderate pain, IV paracetamol is used in combination with an NSAID and tramadol administered parenterally.
– For severe pain, IV paracetamol is used in combination with an NSAID and morphine administered parenterally.
– Paracetamol has no anti-inflammatory properties.
– Do not mix with other drugs in the same infusion bottle.
– Storage: below 25 °C -