PROMETHAZINE injectable

Prescription under medical supervision

Therapeutic action

– Sedating H1 antihistamine

Indications

– Symptomatic treatment of allergic reactions, when oral administration is not possible

Forms and strengths, route of administration

– 50 mg in 2 ml ampoule (25 mg/ml) for deep IM injection

Dosage and duration

– Adult: 25 to 50 mg single dose

Contra-indications, adverse effects, precautions

– Administer with caution and monitor use:
• in elderly patients; 
• in patients with prostate disorders, closed-angle glaucoma, epilepsy, orthostatic hypotension, severe renal or hepatic impairment;
• in patients taking CNS depressants (opioid analgesics, antipsychotics, sedatives, antidepressants, etc.) or drugs known to have an anticholinergic effect (atropine, amitriptyline, chlorpromazine, etc.).
– May cause:
• drowsiness, dizziness, headache, confusion, hypotension, photosensitivity (protect skin from sun exposure); 
• anticholinergic effects (dry mouth, constipation, blurred vision, tachycardia, disorders of micturition); 
• rarely: seizures, extrapyramidal syndrome, neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular disorders), allergic reactions.
– Avoid alcohol during treatment.
– Pregnancy and breast-feeding: avoid

Remarks

  Storage: below 25 °C -