THIAMINE = VITAMIN B1 injectable


Prescription under medical supervision


Therapeutic action

– Vitamin

Indications

– Initial treatment of severe thiamine deficiency: severe acute forms of beriberi, neurological complications of chronic alcoholism (severe polyneuritis, Wernicke’s encephalopathy, Korsakoff syndrome)

Forms and strengths, route of administration

– 100 mg thiamine hydrochloride in 2 ml ampoule (50 mg/ml) for IM or very slow IV route (30 minutes)

Dosage and duration

– Infantile beriberi
25 mg by IV route then, 25 mg by IM route once or 2 times daily then, change to oral route (10 mg once daily) as soon as symptoms have improved.

– Acute beriberi
50 mg by IM injection then change to oral route (50 mg 3 times daily until symptoms improve then, 10 mg once daily)
or, depending on severity, 50 mg by IM injection every 8 hours for a few days then change to oral route (10 mg once daily).

– Wernicke’s encephalopathy, Korsakoff syndrome
250 mg once daily by IV route until the patient can take oral treatment. Higher initial doses may be required during the first 12 hours.

Contra-indications, adverse effects, precautions

– May cause: hypotension; anaphylactic reaction, especially when injected IV (inject very slowly over 30 minutes).
– Pregnancy: no contra-indication
– Breast-feeding: no contra-indication

Remarks

– Thiamine is also called aneurine.
– Injectable thiamine is not included in the WHO list of essential medicines.
– Storagebelow 25 °C -