THIAMINE = VITAMIN B1 injectable

Last updated: August 2021

Prescription under medical supervision


Therapeutic action

– Vitamin

Indications

– Initial treatment of severe thiamine (vitamin B1) deficiency: severe acute forms of beriberi, neurological complications of chronic alcoholism (delirium tremens, Wernicke’s encephalopathy)

Forms and strengths, route of administration

– 100 mg thiamine hydrochloride in 2 ml ampoule (50 mg/ml) for IM or very slow IV route (30 minutes)

Dosage and duration

Infantile beriberi
25 mg by IV route then, 25 mg by IM route once or 2 times daily then, change to oral route (10 mg once daily) as soon as symptoms have improved.

Acute beriberi
50 mg by IM route then change to oral route (50 mg 3 times daily until symptoms improve then, 10 mg once daily)
or, depending on severity, 50 mg by IM route every 8 hours for a few days then change to oral route (10 mg once daily).

– Delirium tremens, Wernicke’s encephalopathy
100 mg by IM or IV route 3 times daily for 3 to 5 days

Contra-indications, adverse effects, precautions

– May cause: hypotension; anaphylactic reaction, especially when injected IV (inject very slowly over 30 minutes).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

– Thiamine is also called aneurine.
– Injectable thiamine is not included in the WHO list of essential medicines.
Storagebelow 25 °C -