Last updated: August 2021
- Initial treatment of severe thiamine (vitamin B1) deficiency: severe acute forms of beriberi, neurological complications of chronic alcoholism (delirium tremens, Wernicke’s encephalopathy)
Forms and strengths, route of administration
- 100 mg thiamine hydrochloride in 2 ml ampoule (50 mg/ml) for IM or very slow IV route (30 minutes)
Dosage and duration
25 mg by IV route then, 25 mg by IM route once or 2 times daily then, change to oral route (10 mg once daily) as soon as symptoms have improved.
50 mg by IM route then change to oral route (50 mg 3 times daily until symptoms improve then, 10 mg once daily)
or, depending on severity, 50 mg by IM route every 8 hours for a few days then change to oral route (10 mg once daily).
Delirium tremens, Wernicke’s encephalopathy
100 mg by IM or IV route 3 times daily for 3 to 5 days
Contra-indications, adverse effects, precautions
- May cause: hypotension; anaphylactic reaction, especially when injected IV (inject very slowly over 30 minutes).
- Pregnancy: no contra-indication
- Breast-feeding: no contra-indication
- Thiamine is also called aneurine.
- Injectable thiamine is not included in the WHO list of essential medicines.