GENTAMICIN injectable

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    Prescription under medical supervision


    Therapeutic action

    • Aminoglycoside antibacterial


    • Severe bacterial infections: meningitis, pneumonia, pyelonephritis, postpartum upper genital tract infections, brucellosis, etc., in combination with other antibacterials

    Forms and strengths, route of administration

    • 80 mg ampoule (40 mg/ml, 2 ml) and 20 mg vial (10 mg/ml, 2 ml), for IM or slow IV injection (3 minutes) or IV infusion (30 minutes) in 0.9% sodium chloride or 5% glucose


    Meningitis in young children, in combination with ampicillin or cloxacillin

    • Neonate:
      •    0 to 7 days (< 2 kg): 3 mg/kg once daily by IV injection or infusion
      •    0 to 7 days (≥ 2 kg): 5 mg/kg once daily by IV injection or infusion
      •    8 days to < 1 month: 5 mg/kg once daily by IV injection or infusion
    • Child 1 to 3 months: 2.5 mg/kg every 8 hours by IV injection or infusion


    Other severe infections

    • Neonate : as above
    • Child 1 month and over and adult: 5 to 6 mg/kg once daily


    For administration by IV infusion, dilute each dose of gentamicin in 5 ml/kg of 0.9% sodium chloride or 5% glucose in children less than 20 kg and in a bag of 100 ml of 0.9% sodium chloride or 5% glucose in children 20 kg and over and in adults.


    • According to indication and clinical response. Given the risk of renal and auditory toxicity, do not prolong treatment unnecessarily.

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with allergy to aminoglycosides or auditory and vestibular damage.
    • Administer with caution and reduce dosage (1 mg/kg daily) in patients with renal impairment.
    • May cause: renal impairment, irreversible auditory and vestibular damage, blockage of neuromuscular transmission, allergic reactions.
    • Do not combine with another aminoglycoside.
    • Monitor combination with: furosemide, amphotericin B, vancomycin (enhanced renal and/or auditory toxicity); neuromuscular blockers, general anaesthetics (potentialization of their effects).
    • Pregnancy: administer only if clearly needed (risk of fetal ototoxicity).
    • Breast-feeding: no contra-indication


    • Do not mix with other drugs in the same syringe or infusion.
    • Gentamicin is also used in the treatment of plague in pregnant and breast-feeding women at a dose of 5 mg/kg once daily for 10 days.


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