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- Antibacterial (group of aminoglycosides)
- Brucellosis, in combination with doxycycline
Forms and strengths, route of administration
- Powder for injection, vial containing 1 g of streptomycin base, to be dissolved in 4 ml of water for injection, for IM injection.
DO NOT ADMINISTER BY IV INJECTION.
- Child: 15 mg/kg every 12 hours (max. 2 g daily)
- Adult: 1 g every 12 hours
- Adult: 1 g once daily
- Plague: 10 days
- Brucellosis: 2 weeks
Contra-indications, adverse effects, precautions
- Do not administer in patients with allergy to aminoglycosides.
- Administer with caution to patients with history of renal, vestibular or auditory problems.
- Reduce the dose in patients with renal impairment.
- May cause: ototoxicity (vestibular and auditory damage), nephrotoxicity, neuropathy, neuromuscular blockade; rarely, allergic reactions.
- Stop treatment in the event of dizziness, paraesthesia, tinnitus or hearing defects (ototoxicity).
- Drink sufficient liquid to limit the risk of renal toxicity.
- Avoid or monitor combination with other ototoxic (e.g. quinine) or nephrotoxic drugs (e.g. other aminoglycosides, amphotericin B, pentamidine).
- Pregnancy: CONTRA-INDICATED
- Breast-feeding: no contra-indication
- The volume of suspension obtained after reconstitution of 1 g of powder in 4 ml of water for injection is 4.83 ml and not 4 ml. The concentration of the suspension is 207 mg/ml and not 250 mg/ml.
– Below 25 °C