STREPTOMYCIN injectable

Therapeutic action

• Antibacterial  (group of aminoglycosides)

Indications

• Alternative to gentamicin in plague 
• Brucellosis, in combination with doxycycline

Forms and strengths, route of administration

• Powder for injection, vial containing 1 g of streptomycin base, to be dissolved in 3.2 ml of water for injection to obtain a 250 mg/ml solution, for IM injection.
• DO NOT ADMINISTER BY IV INJECTION.

Dosage

Plague

• Child: 15 mg/kg (max. 1 g) every 12 hours
• Adult: 1 g every 12 hours

Brucellosis

• Adult: 1 g once daily

Duration

• Plague: 10 to 14 days
• Brucellosis: 2 weeks

Contra-indications, adverse effects, precautions

• Do not administer in patients with allergy to aminoglycosides.
• Administer with caution to patients with history of renal, vestibular or auditory problems.
• Reduce the dose in patients with renal impairment.
• May cause: irreversible ototoxicity (vestibular and auditory damage), nephrotoxicity, neuropathy, paraesthesia, neuromuscular blockade; rarely, allergic reactions.
• Stop treatment in the event of dizziness, tinnitus or hearing loss (ototoxicity).
• Drink sufficient liquid to limit the risk of renal toxicity. 
• Do not combine with another aminoglycoside.
• Avoid or monitor combination with: furosemide, amphotericin B, vancomycin (enhanced renal and/or auditory toxicity); neuromuscular blockers (increased neuromuscular blockage).
• Pregnancy: CONTRA-INDICATED
• Breast-feeding: no contra-indication

Storage