ATROPINE injectable

Prescription under medical supervision

Therapeutic action

– Parasympatholytic, antispasmodic

Indications

– Premedication in anaesthesia
– Spasms of the gastrointestinal tract
– Organophosphorus pesticide poisoning

Forms and strengths, route of administration

– 1 mg atropine sulfate in 1 ml ampoule (1 mg/ml) for SC, IM, IV injection
Also comes in 0.25 mg/ml and 0.5 mg/ml ampoules.

Dosage

– Premedication in anaesthesia
Child: 0.01 to 0.02 mg/kg by SC or IV injection
Adult: 1 mg by SC or IV injection

– Spasms of the gastrointestinal tract
Child from 2 to 6 years: 0.25 mg by SC injection, single dose
Child over 6 years: 0.5 mg by SC injection, single dose
Adult: 0.25 to 1 mg by SC injection, every 6 hours if necessary (max. 2 mg daily)

– Organophosphorus pesticide poisoning
Child: 0.02 to 0.05 mg/kg by IM or slow IV injection
Adult: 2 mg by IM or slow IV injection
Repeat every 5 to 10 minutes until signs of atropinisation appear (reduced secretions, tachycardia, dilatation of the pupils).

Contra-indications, adverse effects, precautions

– Do not administer to patients with urethro-prostatic disorders, cardiac disorders, glaucoma.
– Do not administer to children with high fever.
– May cause: urinary retention, dryness of the mouth, constipation, dizziness, headache, dilatation of the pupils, tachycardia.
– Administer with caution and under close supervision to patients taking other anti cholinergic drugs (antidepressants, neuroleptics, H1 antihistamines, antiparkinsonians, etc.).
– Pregnancy: no contra-indication; NO PROLONGED TREATMENT
– Breast-feeding: avoid; NO PROLONGED TREATMENT

Remarks

– Atropine IV is also used to prevent bradycardic effects of neostigmine when used to reverse the effects of competitive muscle relaxants: 0.02 mg/kg in children; 1 mg in adults.
– Do not mix with other drugs in the same syringe.
 Storage: below 25 °C -