– Long-acting antipsychotic
– Chronic psychosis, maintenance therapy after stabilisation with oral haloperidol
Forms and strengths, route of administration
– 50 mg in 1 ml ampoule (50 mg/ml) for IM injection. DO NOT ADMINISTER BY IV INJECTION.
Dosage and duration
– Adult: one injection every 3 to 4 weeks
The initial dose of haloperidol decanoate corresponds to approximately 10 times the daily dose of oral haloperidol.
50 mg solution
Contra-indications, adverse effects, precautions
– Do not administer to patients with cardiac disorders (cardiac failure, recent myocardial infarction, conduction disorders, bradycardia, etc.), dementia (e.g. Alzheimer's disease), Parkinson's disease and history of neuroleptic malignant syndrome.
– Administer with caution and carefully monitor use in elderly patients and patients with hypokalaemia, hypotension, hyperthyroidism, renal or hepatic impairment, history of seizures.
– May cause: drowsiness, extrapyramidal syndrome, early or tardive dyskinesia, constipation, dry mouth, sexual dysfunction, QT-prolongation, ventricular arrhythmia, orthostatic hypotension.
– In the event of extrapyramidal symptoms, combine with biperiden or trihexyphenidyl.
– Avoid or monitor combination with:
• fluoxetine, paroxetine, sertraline, promethazine, ritonavir (increased plasma concentrations of haloperidol);
• carbamazepine, rifampicin, phenobarbital, phenytoin (decreased plasma concentrations of haloperidol);
• drugs that prolong the QT interval (amiodarone, chloroquine, erythromycin, fluconazole, mefloquine, pentamidine, quinine, etc.).
– Avoid alcohol during treatment.
– Avoid in women of childbearing age or offer effective contraception.
– Pregnancy and breastfeeding: avoid
– Change buttock for each injection.
– Storage: below 25 °C -