HALOPERIDOL decanoate injectable

Prescription under medical supervision

Therapeutic action

– Long-acting antipsychotic

Indications

– Chronic psychosis, maintenance therapy after stabilisation with oral haloperidol

Forms and strengths, route of administration

– 50 mg in 1 ml ampoule (50 mg/ml) for IM injection. DO NOT ADMINISTER BY IV INJECTION.

Dosage and duration

– Adult: one injection every 3 to 4 weeks
The initial dose of haloperidol decanoate corresponds to approximately 10 times the daily dose of oral haloperidol.

Daily dose
oral haloperidol

Monthly dose
haloperidol decanoate IM

50 mg solution
haloperidol decanoate IM

2.5 mg

25 mg

½ amp

5 mg

50 mg

1 amp

10 mg

100 mg

2 amp

15 mg

150 mg

3 amp

Contra-indications, adverse effects, precautions

– Do not administer to patients with cardiac disorders (cardiac failure, recent myocardial infarction, conduction disorders, bradycardia, etc.), dementia (e.g. Alzheimer's disease), Parkinson's disease and history of neuroleptic malignant syndrome.
– Administer with caution and carefully monitor use in elderly patients and patients with hypokalaemia, hypotension, hyperthyroidism, renal or hepatic impairment, history of seizures.
– May cause: drowsiness, extrapyramidal syndrome, early or tardive dyskinesia, constipation, dry mouth, sexual dysfunction, QT-prolongation, ventricular arrhythmia, orthostatic hypotension.
– In the event of extrapyramidal symptoms, combine with biperiden or trihexyphenidyl.
– Avoid or monitor combination with: 
• fluoxetine, paroxetine, sertraline, promethazine, ritonavir (increased plasma concentrations of haloperidol); 
• carbamazepine, rifampicin, phenobarbital, phenytoin (decreased plasma concentrations of haloperidol);
• drugs that prolong the QT interval (amiodarone, chloroquine, erythromycin, fluconazole, mefloquine, pentamidine, quinine, etc.).
– Avoid alcohol during treatment.
– Avoid in women of childbearing age or offer effective contraception.
– Pregnancy and breastfeeding: avoid

Remarks

– Change buttock for each injection.
– Storage: below 25 °C -