HYDROCORTISONE injectable

Prescription under medical supervision


Therapeutic action

– Steroidal anti-inflammatory drug (corticosteroid)

Indications

– Symptomatic treatment of severe allergic and inflammatory reactions, e.g.: severe acute asthma (in addition to inhaled salbutamol), allergic angioedema, anaphylactic shock (as an adjunct to epinephrine)

Forms and strengths, route of administration

– Powder for injection, 100 mg hydrocortisone (hemisuccinate, succinate or phosphate) in vial, to be dissolved in 2 ml water for injection, for IM or slow IV injection or infusion

Dosage and duration

– Child under 1 year: 25 mg/injection
– Child from 1 to 5 years: 50 mg/injection
– Child from 6 to 12 years: 100 mg/injection
– Adult: 100 to 500 mg/injection

Doses may be repeated 3 or 4 times daily according to the severity of the symptoms and the patient’s response.

Contra-indications, adverse effects, precautions

– Avoid prolonged administration in patients with peptic ulcer, diabetes mellitus or cirrhosis.
– Administer with caution to patients receiving digitalis glycosides: increases digitalis toxicity associated with hypokalaemia.
– Pregnancy: use only if clearly needed, for a short period.
– Breast-feeding: no contra-indication

Remarks

– Hydrocortisone acetate is a suspension insoluble in water, used as a local treatment only: intra- or periarticular injection, epidural (sciatic neuralgia).
– Storage: below 25 °C -