AMPICILLIN injectable

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    Last updated: September 2022

     

    Prescription under medical supervision

     

    Therapeutic action

    • Penicillin antibacterial

    Indications

    • Severe bacterial infections: meningitis, pneumonia, severe cutaneous anthrax, pyelonephritis, postpartum upper genital tract infection, etc., in combination with other antibacterials

    Forms and strengths, route of administration

    • Powder for injection, in 500 mg and 1 g vials, to be dissolved in 5 ml of water for injection
    • Prefer administration by slow IV injection (3 to 5 minutes) or IV infusion (30 minutes) in 0.9% sodium chloride or 5% glucose for high doses; use IM route only if correct IV administration is not possible.
    • In neonates, administer only by slow IV injection or IV infusion.

    Dosage

    Meningitis in young children, in combination with cefotaxime or gentamicin 

    • Neonate:
      •    0 to 7 days (< 2 kg): 100 mg/kg every 12 hours 
      •    0 to 7 days (≥ 2 kg): 100 mg/kg every 8 hours 
      •    8 days to < 1 month: 100 mg/kg every 8 hours 
    • Child 1 to 3 months: 100 mg/kg every 8 hours 

     

    Pneumonia and pyelonephritis, in combination with gentamicin

    • Neonate 
      •    0 to 7 days (< 2 kg): 50 mg/kg every 12 hours 
      •    0 to 7 days (≥ 2 kg): 50 mg/kg every 8 hours 
      •    8 days to < 1 month: 50 mg/kg every 8 hours 
    • Child 1 month and over: 50 mg/kg every 6 to 8 hours 
    • Adult: 1 g every 6 or 8 hours (2 g every 6 hours in pyelonephritis) 

     

    Postpartum upper genital tract infection, in combination with metronidazole and gentamicin

    • Adult: 2 g every 8 hours 

     

    Severe cutaneous anthrax, in combination with clindamycin

    • Child 1 month and over: 50 mg/kg (max. 3 g) every 6 hours or 65 mg/kg (max. 4 g) every 8 hours 
    • Adult: 3 g every 6 hours or 4 g every 8 hours

     

    For administration by IV infusion, dilute each dose of ampicillin in 5 ml/kg of 0.9% sodium chloride or 5% glucose in children less than 20 kg and in a bag of 100 ml of 0.9% sodium chloride or 5% glucose in children 20 kg and over and in adults.

    Duration

    • According to indication and clinical response.

     

    Change to oral treatment as soon as possible with amoxicillin or a combination of antibacterials, depending on the indication.

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with infectious mononucleosis (risk of skin eruption) or to penicillin allergic patients.
    • Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur) or patients with severe renal impairment (reduce dosage).
    • May cause: skin eruption, gastrointestinal disturbances, allergic reactions sometimes severe.
    • Do not combine with methotrexate (increased methotrexate toxicity).
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication

    Remarks

    • Do not mix with another drug in the same syringe or infusion.
    • Injectable amoxicillin is used for the same indications.

    Storage

     
    –  Below 25 °C 
    Once reconstituted, the solution must be used immediately.