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    Last updated: February 2024


    Prescription under medical supervision


    Do not exceed the recommended dose and duration of treatment (risk of serious neurological adverse effects).


    Therapeutic action

    • Antiemetic (dopamine antagonist)


    • Prevention or symptomatic treatment of nausea and vomiting in adults

    Forms and strengths, route of administration

    • 10 mg in 2 ml ampoule (5 mg/ml) for IM or slow IV injection (3 to 5 minutes)


    • Adult: 10 mg every 8 hours if necessary


    • Change to oral treatment as soon as possible.

    Contra-indications, adverse effects, precautions

    • Do not administer to children < 18 years or to patients with gastrointestinal haemorrhage, obstruction or perforation.
    • Reduce the dose by half in patients with severe renal impairment.
    • Administer with caution and monitor use in patients > 60 years and patients with epilepsy or Parkinson's disease.
    • May cause: drowsiness, dizziness, confusion, extrapyramidal symptoms, seizures (especially in patients with epilepsy), allergic reactions, cardiac disorders (hypotension, bradycardia, cardiac arrest); neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular disorders), rare but requiring immediate treatment discontinuation.
    • Do not combine with levodopa (antagonism).
    • Avoid combination with CNS depressants (opioid analgesics, antipsychotics, sedatives, antidepressants, antihistamines, etc.) and antihypertensive drugs (increased risk of hypotension).
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication


    • For postoperative nausea and vomiting in adults, efficacy of metoclopramide is limited: ondansetron is preferred.


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