METOCLOPRAMIDE injectable

Therapeutic action

• Antiemetic (dopamine antagonist)

Indications

• Prevention or symptomatic treatment of nausea and vomiting in adults

Forms and strengths, route of administration

• 10 mg in 2 ml ampoule (5 mg/ml) for IM or slow IV injection (3 to 5 minutes)

Dosage

• Adult: 10 mg every 8 hours if necessary

Duration

• Change to oral treatment as soon as possible.

Contra-indications, adverse effects, precautions

• Do not administer to children < 18 years or to patients with gastrointestinal haemorrhage, obstruction or perforation.
• Reduce the dose by half in patients with severe renal impairment.
• Administer with caution and monitor use in patients > 60 years and patients with epilepsy or Parkinson's disease.
• May cause: drowsiness, dizziness, confusion, extrapyramidal symptoms, seizures (especially in patients with epilepsy), allergic reactions, cardiac disorders (hypotension, bradycardia, cardiac arrest); neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular disorders), rare but requiring immediate treatment discontinuation.
• Do not combine with levodopa (antagonism).
• Avoid combination with CNS depressants (opioid analgesics, antipsychotics, sedatives, antidepressants, antihistamines, etc.) and antihypertensive drugs (increased risk of hypotension).
• Pregnancy: no contra-indication
• Breast-feeding: no contra-indication

Remarks

• For postoperative nausea and vomiting in adults, efficacy of metoclopramide is limited: ondansetron is preferred.

Storage