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Given the risk of renal and auditory toxicity, do not prolong treatment unnecessarily.
- Antibacterial (group of aminoglycosides)
- Alternative to gentamicin in plague
- Brucellosis, in combination with doxycycline
Forms and strengths, route of administration
- Powder for injection, vial containing 1 g of streptomycin base, to be dissolved in 3.2 ml of water for injection to obtain a 250 mg/ml solution, for IM injection.
- DO NOT ADMINISTER BY IV INJECTION.
- Child: 15 mg/kg (max. 1 g) every 12 hours
- Adult: 1 g every 12 hours
- Adult: 1 g once daily
- Plague: 10 to 14 days
- Brucellosis: 2 weeks
Contra-indications, adverse effects, precautions
- Do not administer in patients with allergy to aminoglycosides.
- Administer with caution to patients with history of renal, vestibular or auditory problems.
- Reduce the dose in patients with renal impairment.
- May cause: irreversible ototoxicity (vestibular and auditory damage), nephrotoxicity, neuropathy, paraesthesia, neuromuscular blockade; rarely, allergic reactions.
- Stop treatment in the event of dizziness, tinnitus or hearing loss (ototoxicity).
- Drink sufficient liquid to limit the risk of renal toxicity.
- Do not combine with another aminoglycoside.
- Avoid or monitor combination with: furosemide, amphotericin B, vancomycin (enhanced renal and/or auditory toxicity); neuromuscular blockers (increased neuromuscular blockage).
- Pregnancy: CONTRA-INDICATED
- Breast-feeding: no contra-indication
– Below 25 °C