STREPTOMYCIN injectable

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    Last updated: September 2022

     

    Prescription under medical supervision
     
     
     

     

     
     

    Given the risk of renal and auditory toxicity, do not prolong treatment unnecessarily.

     

    Therapeutic action

    • Antibacterial  (group of aminoglycosides)

    Indications

    • Alternative to gentamicin in plague 
    • Brucellosis, in combination with doxycycline

    Forms and strengths, route of administration

    • Powder for injection, vial containing 1 g of streptomycin base, to be dissolved in 3.2 ml of water for injection to obtain a 250 mg/ml solution, for IM injection.
    • DO NOT ADMINISTER BY IV INJECTION.

    Dosage

    Plague

    • Child: 15 mg/kg (max. 1 g) every 12 hours
    • Adult: 1 g every 12 hours

     

    Brucellosis

    • Adult: 1 g once daily

    Duration

    • Plague: 10 to 14 days
    • Brucellosis: 2 weeks

    Contra-indications, adverse effects, precautions

    • Do not administer in patients with allergy to aminoglycosides.
    • Administer with caution to patients with history of renal, vestibular or auditory problems.
    • Reduce the dose in patients with renal impairment.
    • May cause: irreversible ototoxicity (vestibular and auditory damage), nephrotoxicity, neuropathy, paraesthesia, neuromuscular blockade; rarely, allergic reactions.
    • Stop treatment in the event of dizziness, tinnitus or hearing loss (ototoxicity).
    • Drink sufficient liquid to limit the risk of renal toxicity. 
    • Do not combine with another aminoglycoside.
    • Avoid or monitor combination with: furosemide, amphotericin B, vancomycin (enhanced renal and/or auditory toxicity); neuromuscular blockers (increased neuromuscular blockage).
    • Pregnancy: CONTRA-INDICATED
    • Breast-feeding: no contra-indication

    Storage

     
    –  Below 25 °C