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- General anaesthetic
- Induction and maintenance of general anaesthesia
Forms and strengths, route of administration
- 250 mg in 5 ml ampoule (50 mg/ml) for IM, IV injection or infusion
Child and adult:
- IV: 2 mg/kg to be injected slowly. Anaesthesia is produced within one minute and lasts 10 to 15 minutes.
- IM: 8 to 10 mg/kg. Anaesthesia is produced within 5 minutes and lasts 15 to 30 minutes.
- IV: 0.5 to 1 mg/kg depending on recovery signs (approximately every 15 minutes)
- IM: 5 mg/kg approximately every 20 to 30 minutes
- Depending on duration of the operation
Contra-indications, adverse effects, precautions
- Do not administer to patients with intraocular hypertension, pre-eclampsia.
- Administer with caution to patients with arterial or intracranial hypertension, coronary insufficiency, psychiatric disorders.
- May cause: hypertension, hypersalivation, hallucinations during recovery (less frequent in children or when injected IM), apnoea following rapid IV injection.
- Premedication to prevent hypersalivation and hallucinations:
- atropine IV: 0.01 to 0.015 mg/kg + diazepam slow IV: 0.1 mg/kg, during induction
- atropine IM: 0.01 to 0.015 mg/kg + diazepam IM: 0.1 mg/kg, 30 minutes before induction
- Technical equipment for intubation and ventilation must be available and ready for use.
- Pregnancy: no contra-indication, except in pre-eclampsia. For ceaserean sections, do not exceed 1 mg/kg by IV injection (risk of neonatal respiratory depression at higher doses).
- Breast-feeding: no contra-indication
- Ketamine has no muscle relaxant properties.
- In some countries, ketamine is on the list of narcotics: follow national regulations.
- Also comes in 10 ml ampoule containing 500 mg (50 mg/ml).
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