CEFTRIAXONE injectable

Prescription under medical supervision


Therapeutic action

– Third-generation cephalosporin antibacterial

Indications

– Severe bacterial infections: meningitis, pneumonia, typhoid fever, shigellosis, leptospirosis, pyelonephritis, neurosyphilis, etc.
– Cervicitis, urethritis and conjunctivitis due to Neisseria gonorrhoeae (in combination with a treatment for chlamydia, except in neonates), chancroid

Forms and strengths, route of administration

– Powder for injection, in 250 mg or 1 g vials, to be dissolved:
• with the solvent containing lidocaine for IM injection only. DO NOT ADMINISTER BY IV INJECTION OR INFUSION the solution reconstituted with this solvent.
• with water for injection for slow IV injection (3 minutes) or infusion (30 minutes) in 0,9% sodium chloride or 5% glucose

Dosage and duration

 Severe bacterial infections
Child 1 month and over: 50 to 100 mg/kg once daily (max. 2 g daily and 4 g daily for typhoid fever and meningitis)
Adult: 1 to 2 g once daily (up to 2 g once daily or 2 times daily for typhoid fever and meningitis)
Duration varies according to indication and clinical response.

– Gonococcal cervicitis and urethritis, chancroid
Child under 45 kg: 125 mg IM single dose
Child 45 kg and over and adult: 250 mg IM single dose

 Gonococcal conjunctivitis
Neonate: 50 mg/kg IM single dose (max. 125 mg)
Adult: 1 g IM single dose

For administration by IV route, ceftriaxone powder is to be reconstituted in water for injection only. for administration by IV infusion, dilute each dose of ceftriaxone in 5 ml/kg of 0.9% sodium chloride or 5% glucose in children less than 20 kg and in a bag of 100 ml of 0.9% sodium chloride or 5% glucose in children 20 kg and over and in adults.

Contra-indications, adverse effects, precautions

– Do not administer to patients with allergy to cephalosporins or penicillins (cross-sensitivity may occur) and to neonates with jaundice (risk of bilirubin encephalopathy).
– Administer with caution in patients with hepatic or renal impairment. reduce dosage in patients with severe renal impairment (max. 50 mg/kg daily or 2 g daily in IV).
– May cause: gastrointestinal disturbances, hepatic dysfunction, blood disorders (anaemia, leucopenia, neutropenia), renal dysfunction; allergic reactions sometimes severe (Stevens-johnson syndrome).
– Do not mix ceftriaxone with calcium-containing solutions such as ringer lactate (risk of particulate formation).
– Pregnancy: no contra-indication
– Breast-feeding: no contra-indication

Remarks

– Doses greater than 1 g IM should be administered in 2 equally divided injections (one in each buttock). Doses greater than 2 g should be administered by IV infusion only.
– Do not mix with another drug in the same syringe or infusion.
– Storage: below 25 °C - 
Once reconstituted, the solution must be used immediately.