METOCLOPRAMIDE injectable

Prescription under medical supervision


Therapeutic action

– Antiemetic (dopamine antagonist)

Indications

– Prevention or symptomatic treatment of nausea and vomiting in adults

Forms and strengths, route of administration

– 10 mg in 2 ml ampoule (5 mg/ml) for IM or slow IV injection (3 to 5 minutes)

Dosage

– Adult: 10 mg every 8 hours if necessary

Duration

– According to clinical evolution, as short as possible

Contra-indications, adverse effects, precautions

– Do not administer to children < 18 years and to patients with gastrointestinal haemorrhage, obstruction or perforation.
– Reduce the dose by half in patients with severe renal impairment.
– Administer with caution and monitor use in patients > 60 years and patients with epilepsy or Parkinson's disease.
– May cause: drowsiness, dizziness, confusion, extrapyramidal symptoms, seizures (especially in epileptics), allergic reactions, cardiac disorders (hypotension, bradycardia, cardiac arrest); neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular disorders), rare but requiring immediate treatment discontinuation.
– Do not combine with levodopa (antagonism).
– Avoid combination with CNS depressants (opioid analgesics, antipsychotics, sedatives, antidepressants, antihistamines, etc.) and antihypertensive drugs (increased risk of hypotension).
– Pregnancy: no contra-indication
– Breast-feeding: no contra-indication

Remarks

– For postoperative nausea and vomiting in adults, efficacy of metoclopramide is limited: ondansetron is preferred.
– Metoclopramide is also used as a gastrointestinal prokinetic agent in patients receiving enteral feeding by a nasogastric tube in intensive care units.
– Storage: below 25 °C -