STREPTOMYCIN injectable

Prescription under medical supervision


Therapeutic action

– Antibacterial  (group of aminoglycosides)

Indications

– Plague
– Brucellosis, in combination with doxycycline

Forms and strengths, route of administration

– Powder for injection, vial containing 1 g of streptomycin base, to be dissolved in 4 ml of water for injection, for IM injection. DO NOT ADMINISTER BY IV INJECTION.

Dosage

Plague
Child: 15 mg/kg every 12 hours (max. 2 g daily)
Adult: 1 g every 12 hours

– Brucellosis

Adult: 1 g once daily

Duration

Plague: 10 days; brucellosis: 2 weeks

Contra-indications, adverse effects, precautions

– Do not administer in patients with allergy to aminoglycosides.
– Administer with caution to patients with history of renal, vestibular or auditory problems.
– Reduce the dose in patients with renal impairment.
– May cause: ototoxicity (vestibular and auditory damage), nephrotoxicity, neuropathy, neuromuscular blockade; rarely, allergic reactions.
– Stop treatment in the event of dizziness, paraesthesia, tinnitus or hearing defects (ototoxicity).
– Drink sufficient liquid to limit the risk of renal toxicity.
– Avoid or monitor combination with other ototoxic (e.g. quinine) or nephrotoxic drugs (e.g. other aminoglycosides, amphotericin B, pentamidine).
PregnancyCONTRA-INDICATED
Breast-feeding: no contra-indication

Remarks

– The volume of suspension obtained after reconstitution of 1 g of powder in 4 ml of water for injection is 4.83 ml and not 4 ml. The concentration of the suspension is 207 mg/ml and not 250 mg/ml.
Storage: below 25 °C -