TRANEXAMIC acid injectable

Prescription under medical supervision


Therapeutic action

– Antifibrinolytic

Indications

– Postpartum haemorrhage

Presentation and route of administration

– 500 mg in 5 ml ampoule (100 mg/ml) for slow IV injection or infusion in 0.9% sodium chloride or 5% glucose
DO NOT ADMINISTER BY IM ROUTE.

Dosage and duration

– Adolescent under 15 years: 15 mg/kg (max. 1 g)
– Adult: 1 g (two 5 ml ampoules) in a bag of 100 ml of 0.9% sodium chloride to be administered over 15 minutes within 3 hours of delivery. Repeat after 30 minutes if bleeding continues or within 24 hours of the first dose if bleeding restarts (max. total dose 2 g).

Contra-indications, adverse effects, precautions

– Do not administer to patients with (or with history of) venous or arterial thromboembolic disorders, severe renal impairment, history of seizures.  
– May cause: gastrointestinal disturbances, hypotension and malaise if injected rapidly (rate > 1 ml/minute); rarely, seizures with high doses, blurred vision, allergic reactions.
– Reduce dosage in patients with mild to moderate renal impairment (risk of accumulation).
– Avoid combination with drugs that increase the risk of thromboembolism (e.g. oestrogenes).

Remarks

– Tranexamic acid is also used in the management of trauma patients with significant haemorrhage, at the same dosage, by slow IV injection or infusion, to be administered within the first hour after injury and a second dose 3 hours after the first dose. 3 hours after injury, tranexamic acid is no longer indicated as its administration increases the risk of death.
– Tranexamic acid is not indicated in the management of prepartum haemorrhage.
– Do not mix with benzylpenicillin (incompatibility).
– Storage: below 25 °C -