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Therapeutic action
- Long-acting antipsychotic
Indications
- Chronic psychosis, maintenance therapy after stabilisation with oral haloperidol
Forms and strengths, route of administration
- 50 mg in 1 ml ampoule (50 mg/ml) for IM injection
- DO NOT ADMINISTER BY IV INJECTION.
Dosage and duration
- Adult: one injection every 3 to 4 weeks
The initial dose of haloperidol decanoate corresponds to approximately 10 times the daily dose of oral haloperidol.
Daily dose oral haloperidol |
Monthly dose haloperidol decanoate IM |
50 mg solution haloperidol decanoate IM |
---|---|---|
2.5 mg | 25 mg | ½ amp |
5 mg | 50 mg | 1 amp |
10 mg | 100 mg | 2 amp |
15 mg | 150 mg | 3 amp |
Contra-indications, adverse effects, precautions
- Do not administer to patients with cardiac disorders (cardiac failure, recent myocardial infarction, conduction disorders, bradycardia, etc.), dementia (e.g. Alzheimer's disease), Parkinson's disease and history of neuroleptic malignant syndrome.
- Administer with caution and carefully monitor use in older patients and patients with hypokalaemia, hypotension, hyperthyroidism, renal or hepatic impairment, history of seizures.
- May cause: drowsiness (caution when driving/operating machinery), extrapyramidal syndrome, early or tardive dyskinesia, constipation, dry mouth, sexual dysfunction, QT-prolongation, ventricular arrhythmia, orthostatic hypotension.
- In case of extrapyramidal symptoms, try reducing the dose of haloperidol decanoate or, if the extrapyramidal symptoms are severe, add biperiden or trihexyphenidyl.
- Avoid or monitor combination with:
- fluoxetine, paroxetine, sertraline, promethazine, ritonavir (increased plasma concentrations of haloperidol);
- carbamazepine, rifampicin, phenobarbital, phenytoin (decreased plasma concentrations of haloperidol);
- drugs that prolong the QT interval (amiodarone, chloroquine, erythromycin, fluconazole, mefloquine, pentamidine, quinine, etc.).
- Avoid alcohol during treatment (increased risk of adverse effects).
- Avoid in women of childbearing age or offer effective contraception.
- Pregnancy and breastfeeding: avoid
Remarks
- Change buttock for each injection.
Storage
– Below 25 °C