GENTAMICIN injectable

Prescription under medical supervision

Therapeutic action

– Aminoglycoside antibacterial

Indications

– Severe bacterial infections: meningitis, pneumonia, pyelonephritis, postpartum upper genital tract infections, brucellosis, etc., in combination with other antibacterials

Forms and strengths, route of administration

80 mg ampoule (40 mg/ml, 2 ml) and 20 mg vial (10 mg/ml, 2 ml), for IM or slow IV injection (3 minutes) or IV infusion (30 minutes) in 0.9% sodium chloride or 5% glucose

Dosage

Meningitis in young children, in combination with ampicillin or cloxacillin
• Neonate:
   0 to 7 days (< 2 kg): 3 mg/kg once daily by IV injection or infusion
   0 to 7 days (≥ 2 kg): 5 mg/kg once daily by IV injection or infusion
   8 days to < 1 month: 5 mg/kg once daily by IV injection or infusion
• Child 1 to 3 months: 2.5 mg/kg every 8 hours by IV injection or infusion

Other severe infections
• Neonate : as above
• Child 1 month and over and adult: 5 to 6 mg/kg once daily

For administration by IV infusion, dilute each dose of gentamicin in 5 ml/kg of 0.9% sodium chloride or 5% glucose in children less than 20 kg and in a bag of 100 ml of 0.9% sodium chloride or 5% glucose in children 20 kg and over and in adults.

Duration

– According to indication and clinical response. Given the risk of renal and auditory toxicity, do not prolong treatment unnecessarily.

Contra-indications, adverse effects, precautions

– Do not administer to patients with allergy to aminoglycosides or auditory and vestibular damage.
– Administer with caution and reduce dosage (1 mg/kg daily) in patients with renal impairment.
– May cause: renal impairment, irreversible auditory and vestibular damage, blockage of neuromuscular transmission, allergic reactions.
– Do not combine with another aminoglycoside.
– Monitor combination with: furosemide, amphotericin B, vancomycin (enhanced renal and/or auditory toxicity); neuromuscular blockers, general anaesthetics (potentialization of their effects).
Pregnancy: administer only if clearly needed (risk of fetal ototoxicity).
Breast-feeding: no contra-indication

Remarks

– Do not mix with other drugs in the same syringe or infusion.
– Gentamicin is also used in the treatment of plague in pregnant and breast-feeding women at a dose of 5 mg/kg once daily for 10 days.
Storage: below 25 °C